For treating pediatric cancers, girls receive a chest radiotherapy. Essential element of support, this technique exposed however to an increased risk of developing breast cancer later. This driving would be comparable to that of women with genetic predispositions to disease. The results of this study presented to the US Congress of cancer advocates early screening.
Women who received radiation therapy to treat cancer in childhood should be screened for early breast cancer. Radiation therapy remains an essential element of support of many pediatric cancers. But this technique can increase the risk of developing breast cancer chest exposure. But in what proportion? Out the1 study presented at the American Congress on cancer ASCO 2012 sought to compare this risk to that related to genetic predispositions. We analyzed the data over 1 200 women who had chest radiation therapy to treat pediatric cancer. The risk associated with genetic predispositions (genes BRCA1/BRCA2 alterations) was evaluated on the study WECARE including 4 570 women with a relative of first degree of breast cancer and who was in life a year after diagnosis.
For those having a pediatric cancer, close to a woman aged 50 years on 4 (24%) had breast cancer. Among those treated for Hodgkin’s lymphoma, the disease was almost one woman in three (30%), a risk the same as women with genetic predisposition BRCA1 (31%) – the risk associated with BRCA2 is estimated at 10%. In comparison, the risk to the general population of women 50 years of age is 4%.
For women who received high doses of radiation (20 Gy or more) at the level of the chest, the Group of us Pediatric oncologist recommended annual mammography and MRI, as early as 25 years or 8 years after radiotherapy. But according to Dr. Chaya s. Moskowitz of Memorial Sloan-Kettering Cancer Center (New York) and main author of the study, this recommendation should also apply to women who received lower doses. According to its results, 7% of women treated with low doses at the thoracic level (of the order of 10 to 19 Gy) have had a breast cancer in 40 years, compared to 12% of women treated with higher doses (20 Gy or more). A non-négligeable… risk “Our results suggest that women treated with more low doses of radiation and which are not currently detected also have higher breast cancer risk.” It should therefore benefit from the same screening strategies”concludes Dr. Chaya Moskowitz.”
In France, the national cancer Institute launched an appeal projects to experiment with, over a period of 18 months, the implementation of a custom program of the après-cancer (CHP) that fits over the long term for those who have had cancer in childhood. This program is one of the 6 lights of the cancer 2009-2013 plan. Today, 5 pilot projects were selected by the CNIB to implement this CHP2.